FROST PHILLIP MD ET AL — Form SCHEDULE 13D/A

Amendment No. 28 to Schedule 13D filed by Dr. Phillip Frost and related entities (Gamma Trust, Frost Nevada Trust, Philanthropic Foundation) updates their beneficial ownership of OPKO Health, Inc. common stock as of June 29, 2026. Dr. Frost controls 255,429,406 shares (34.1% of 746,328,225 outstanding shares): Gamma Trust holds 216,706,448 shares (29.0%), Frost Nevada holds 30,127,177 shares (4.0%), Dr. Frost individually holds 3,068,951 shares plus 2,425,000 exercisable options and 250,000 RSUs vesting within 60 days, and the Philanthropic Foundation holds 2,851,830 shares. No transactions occurred in the preceding 60 days; filing is required solely due to change in Issuer's outstanding share count.